Molecular basis of the potential of mesalazine to prevent colorectal cancer

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:lixu0033
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Patients with ulcerative colitis (UC) and Crohn’s disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Although conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to treat inflammation, such as mesalazine, can reduce the incidence of colitis-associated CRC. Therefore, in recent years, several studies have been conducted to dissect the mechanisms by which mesalazine interferes with CRC cell growth and survival. This review summarizes the current information on the molecular mechanisms that underlie the antineoplastic action of mesalazine. Patients with ulcerative colitis (UC) and Crohn’s disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Both conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to treat inflammation, such as asalazine, can reduce the incidence of colitis-associated CRC. summarizes the current information on the molecular mechanisms that underlie the antineoplastic action of mesalazine.
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