染色体不稳定性综合征(毛细血管扩张性失调,范可尼氏贫血,werner’s 和Bloom’s 综合征)的染色体畸变高频率与癌症易感性之间的相互关系已经明确。染色体的不稳定性也存在于其他疾病和恶性疾病中,例如:多发性内分泌腺瘤、小脑共济失调和系统性硬化,视网膜母细胞瘤、肾癌、家族性多发性结肠息肉、皮肤癌以及两种原发性肿瘤的患者;宫颈癌溃疡、遗传性 The relationship between the high frequency of chromosomal aberrations and cancer susceptibility to chromosomal instability syndromes (telangiectasia disorder, Fanconi’s anemia, werner’s, and Bloom’s syndrome) is well established. Chromosomal instability is also present in other diseases and malignant diseases such as multiple endocrine adenomas, cerebellar ataxia and systemic sclerosis, retinoblastoma, renal cancer, familial multiple colon polyps, skin cancer, and Patients with two primary tumors; Cervical ulcers, hereditary