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目的观察甘氨双唑钠联合顺铂治疗局部晚期鼻咽癌的近期疗效及毒副作用。方法 8鼻咽癌初治患者随机分成治疗组和对照组,治疗组40例,对照组40例。两组均采用6MV的直线加速器进行常规放疗,鼻咽原发灶DT66-76GY/7～8w,颈部转移灶DT60～70GY/6～7w,颈部预防量50GY/5w。并予顺铂40mg.m-2,每周1次,共7次,均在放疗d1用药。其中治疗组同期配合甘氨双唑钠800mg/m2放疗前1h静脉滴注,每周3次。结果肿瘤消退情况:放疗结束时鼻咽肿块完全消退率治疗组和对照组分别为92.5%和75%,P<0.05,近期疗效治疗组好于对照组。急性毒副反应两组无明显差异。结论甘氨双唑钠联合顺铂方案可以提高局部晚期鼻咽癌的肿瘤消退率,近期疗效优于顺铂增敏,无明显的急性毒副作用。
Objective To observe the short-term curative effect and side effects of glycopyrrolate combined with cisplatin in the treatment of locally advanced nasopharyngeal carcinoma. Methods 8 patients with nasopharyngeal carcinoma were randomly divided into treatment group and control group, 40 cases in the treatment group and 40 cases in the control group. Both groups were treated with 6MV linear accelerator for conventional radiotherapy. The primary tumor of the nasopharynx DT66-76GY / 7 ~ 8w, the neck metastases DT60 ~ 70GY / 6 ~ 7w, the neck prevention dose 50GY / 5w. And to cisplatin 40mg.m-2, once a week for a total of 7 times, d1 were treated with radiotherapy. The treatment group with the same period of sodium glycididazol 800mg / m2 1h before radiotherapy intravenous infusion, 3 times a week. Results Tumor regression: The complete regression rate of nasopharyngeal mass at the end of radiotherapy was 92.5% and 75% respectively in the treatment group and the control group (P <0.05). The treatment effect in the short term was better than that in the control group. There was no significant difference in acute toxicities between the two groups. Conclusions The combination of glycopyrrolate sodium and cisplatin can improve the rate of tumor regression in locally advanced nasopharyngeal carcinoma. The recent curative effect is superior to cisplatin in sensitization and no obvious acute side effects.