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[目的]分析鼻咽癌患者调强放疗后的预后因素。[方法]2005年3月至2009年5月136例经病理证实鼻咽低分化鳞状细胞癌患者入组,所有病例行调强放疗治疗后定期随访,中位随访期38个月(5～74个月)。[结果]Kaplan-Meier分析显示性别对无瘤生存率有显著性影响(P=0.039),T分期、N分期、临床分期对无转移生存率(P值分别为0.017、0.006、0.012)和无瘤生存率(P值分别为0.007、0.017、0.011)有显著性影响。Cox回归模型分析显示临床分期是无转移生存率(RR=2.963,P=0.002)和无瘤生存率(RR=2.520,P=0.002)的独立预后因素。[结论]临床分期为鼻咽癌的独立预后因素,2008分期系统能够很好地预测鼻咽癌的生存状况。
[Objective] To analyze the prognostic factors of patients with nasopharyngeal carcinoma after IMRT. [Methods] From March 2005 to May 2009, 136 patients with histologically confirmed poorly differentiated squamous cell carcinoma of the nasopharynx were included in the study. All patients were followed up regularly with intensity modulated radiotherapy. The median follow - up period was 38 months (range, 74 months). [Results] The Kaplan-Meier analysis showed that gender had significant effect on the tumor-free survival rate (P = 0.039), T stage, N stage and clinical stage for no metastasis survival rate (P = 0.017,0.006,0.012, respectively) Tumor survival rate (P values were 0.007,0.017,0.011 respectively) had a significant effect. Cox regression analysis showed that clinical stage was an independent prognostic factor for no-transfer survival (RR = 2.963, P = 0.002) and no tumor-free survival (RR = 2.520, P = 0.002). [Conclusion] The clinical stage is the independent prognostic factor of nasopharyngeal carcinoma. 2008 staging system can predict the survival of nasopharyngeal carcinoma.