家兔感染日本血吸虫尾蚴3至10周,用吡喹酮40 mg/kg ig 1次治疗时,疗效以感染3周组的为最差,感染5周组的疗效明显增加,而以感染8及10周组的最好,全部或大部分受治兔的雌虫被杀灭。这一结果与宿主特异性抗体的有无和抗体水平的增长相一致,而与细胞的免疫水平则无密切的平行关系。进一步的试验结果表明,吡喹酮对虫龄为3周童虫的疗效与特异性抗体的存在有密切关系。 Rabbits infected with Schistosoma japonicum cercariae 3 to 10 weeks, with praziquantel 40 mg / kg ig 1 treatment, the efficacy of infection in the 3-week group was the worst, 5-week infection group significantly increased the efficacy, and infection 8 and The best, all, or most of the treated rabbits in the 10 week group were killed. This result is consistent with the presence or absence of host-specific antibodies and the increase in antibody levels, with no close parallel to cellular immunity. Further tests showed that praziquantel is effective in the treatment of 3-week-old worms with the presence of specific antibodies.