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目的运用Meta分析法对父母氯酚类职业接触与儿童白血病、淋巴瘤的关联性作出综合评价。方法通过计算机检索所有有关氯酚类职业接触与儿童白血病和淋巴瘤关联性的文献,去除不符合纳入条件的文献,根据入选文献的异质性检验结果,确定采用固定或随机效应模型进行比值比(OR)合并分析,结合漏斗图和Egger’s线性回归检验来评估发表偏倚。结果共有7篇公开发表的文献进入Meta分析,结果表明:氯酚类职业接触与儿童白血病和淋巴瘤之间的合并OR值及95%置信区间(CI)分别为1.59和1.26～2.02;父亲氯酚类职业接触OR值为1.65,95%CI为0.84～3.22,母亲氯酚类职业接触OR值为1.58,95%CI为1.23～2.04。结论父母氯酚类职业接触与儿童白血病和淋巴瘤间有关联性。
OBJECTIVE: To make a comprehensive assessment of the association of chlorophenolate-induced occupational exposure with childhood leukemia and lymphoma using Meta-analysis. Methods All the literature about the association of chlorophenolate occupational exposure with childhood leukemia and lymphoma was retrieved by computer and the documents that did not meet the inclusion criteria were removed. Based on the heterogeneity test results of the selected articles, the odds ratio (OR) pooled analysis, combined with funnel plot and Egger’s linear regression test to assess publication bias. Results A total of 7 published papers were included in the meta-analysis. The results showed that the combined odds ratio (OR) and 95% confidence interval (CI) of chlorophenolate occupational exposure to childhood leukemia and lymphoma were 1.59 and 1.26 to 2.02, respectively. The OR of occupational exposure to phenols was 1.65, the 95% CI was 0.84 to 3.22, the OR of occupational exposure to chlorophenols was 1.58, and the 95% CI was 1.23 to 2.04. Conclusion There is a correlation between parental chlorophenolate occupational exposure and childhood leukemia and lymphoma.