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目的探讨老年代谢综合征患者阿司匹林抵抗的罹患率及其与环氧化酶-2(COX-2)基因-765G>C多态性的关系。方法 106位老年代谢综合征患者口服阿司匹林100mg/d至少20天,根据Chrono-log560CA全血发光血小板聚集系统检测结果分为阿司匹林抵抗(AR)组或阿司匹林敏感(AS)组,然后应用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)技术分析COX-2基因-765G>C多态性。结果老年代谢综合征患者中阿司匹林抵抗的罹患率为31.13%,-765G>C多态性三种基因型GG、GC和CC的分布频率分别为68.9%、22.6%和8.5%,-765C等位基因分布频率为19.8%。AR和AS两组患者-765G>C多态性的基因型(p=0.553)和等位基因(p=0.714)分布频率没有显著差异。结论 COX-2基因-765G>C多态性与老年代谢综合征患者阿司匹林抵抗无关。
Objective To investigate the prevalence of aspirin resistance in elderly patients with metabolic syndrome and its relationship with the polymorphism of cyclooxygenase-2 (COX-2) -765G> C. Methods 106 elderly patients with metabolic syndrome were treated with oral aspirin 100mg / d for at least 20 days. According to the Chrono-log560CA whole blood luminescence platelet aggregation system, the patients were divided into aspirin resistance (AR) group and aspirin sensitive (AS) group. Response and restriction fragment length polymorphism (PCR-RFLP) analysis of COX-2 gene -765G> C polymorphism. Results The prevalence of aspirin resistance in elderly patients with metabolic syndrome was 31.13%. The distribution frequencies of GG, GC and CC in the polymorphism of-765G> C were 68.9%, 22.6% and 8.5%, and-765C, respectively The frequency of gene distribution was 19.8%. There was no significant difference in the distribution frequency of genotypes (p = 0.553) and alleles (p = 0.714) for the -765G> C polymorphism between AR and AS groups. Conclusion The -765G> C polymorphism of COX-2 gene is not associated with aspirin resistance in elderly patients with metabolic syndrome.