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目的探讨小儿喘息性支气管炎采用孟鲁司特钠治疗的临床效果。方法 60例小儿喘息性支气管炎患儿,按照随机数字法分为对照组和研究组,各30例。对照组患儿采用常规治疗,研究组患儿采用孟鲁司特钠治疗。比较两组患儿临床疗效、咳嗽消失时间、哮鸣音消失时间、气喘消失时间、住院时间以及白细胞介素-12(IL-12)、白细胞介素-10(IL-10)、嗜酸粒细胞阳离子蛋白(ECP)、外周血白三烯E4(LTE4)水平。结果研究组患儿总有效率为96.67%,显著高于对照组的80.00%,差异具有统计学意义(P<0.05)。研究组咳嗽消失时间、哮鸣音消失时间、气喘消失时间及住院时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患儿IL-10、ECP及LTE4水平均显著降低,IL-12水平均显著升高,且研究组较对照组改善显著,差异具有统计学意义(P<0.05)。两组患儿均未出现呕吐、恶心、心悸、头痛、过敏等不良反应。结论在小儿喘息性支气管炎患儿治疗中选择孟鲁司特钠治疗可显著改善患儿的气道高反应性,具有确切疗效,值得在临床上推广使用。
Objective To investigate the clinical efficacy of montelukast sodium in children with asthmatic bronchitis. Methods Sixty children with asthmatic bronchitis were divided into control group and study group according to random number method, 30 cases in each group. Control children with conventional treatment, the study group treated with montelukast sodium. The clinical curative effect, cough disappearing time, disappearance of wheeze, time of asthma disappearance, length of hospital stay and the levels of interleukin-12 (IL-12), interleukin-10 Cytosolic protein (ECP), leukotriene E4 (LTE4) levels. Results The total effective rate of the study group was 96.67%, which was significantly higher than that of the control group (80.00%), the difference was statistically significant (P <0.05). The study group cough disappear time, wheeze disappear time, asthma disappear time and hospitalization time are shorter than the control group, the difference was statistically significant (P <0.05). After treatment, the levels of IL-10, ECP and LTE4 in both groups were significantly decreased, IL-12 levels were significantly increased, and the study group improved significantly compared with the control group, the difference was statistically significant (P <0.05). Two groups of children did not appear vomiting, nausea, heart palpitations, headache, allergies and other adverse reactions. Conclusion The treatment of children with asthmatic bronchitis in the treatment of montelukast sodium can significantly improve children with airway hyperresponsiveness, with the exact effect, it is worth promoting in clinical use.