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目的:评价盐酸二甲双胍缓释片治疗2型糖尿病的疗效和安全性。方法:以盐酸二甲双胍普通片为对照药,用随机单盲对照试验研究。结果:两组(盐酸二甲双胍缓释片组和盐酸二甲双胍普通片组)间治疗后空腹血糖、餐后2小时血糖、糖化血红蛋白、总胆固醇、甘油三酯和高密度脂蛋白偏离基线值的差别均无统计学意义。两组间治疗后低密度脂蛋白偏离基线值比较,差别有统计学意义,盐酸二甲双胍缓释片组的降低值高于盐酸二甲双胍普通片组,两组间不良反应发生率的差异无统计学意义。结论:盐酸二甲双胍缓释片能显著降低低密度脂蛋白水平。患者耐受性好,不良反应轻微。
Objective: To evaluate the efficacy and safety of metformin hydrochloride sustained-release tablets in the treatment of type 2 diabetes mellitus. Methods: Metformin hydrochloride tablets as a control, randomized single-blind controlled study. Results: The difference of fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride and high density lipoprotein between the two groups (metformin hydrochloride sustained-release tablets and metformin hydrochloride common tablets) No statistical significance. The difference between the two groups after treatment was significant (P <0.05), and the difference was statistically significant. The decrease of metformin hydrochloride sustained-release tablets was higher than that of metformin hydrochloride tablets. There was no significant difference in the incidence of adverse reactions between the two groups . Conclusion: Metformin hydrochloride sustained-release tablets can significantly reduce the level of LDL. Patients are well tolerated with mild adverse reactions.