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目的探讨盐酸非那嗪奈(fenazinel dihydrochloride,FD)对易卒中型自发性高血压大鼠(stroke-prone sponta-neously hypertensive rat,SHRSP)脑卒中的预防和治疗作用。方法 7周龄大小的SHRSP,令其每日摄入约1 g食盐以促进脑卒中的发生,同时每日腹腔注射剂量为1、3、10 mg/kg的FD。观察SHRSP脑卒中发生时间、存活时间和脑卒中后的神经症状的改变。结果FD可延缓SHRSP的脑卒中发生时间,延长动物脑卒中发生后的存活时间(P<0.05或P<0.01),低、中剂量还可减轻动物发生脑卒中后的神经症状(P<0.05或P<0.01)。结论 FD对SHRSP有一定的抗脑卒中作用。
Objective To investigate the preventive and therapeutic effects of fenazinel dihydrochloride (FD) on stroke in spontaneously hypertensive rats (stroke-prone sponta-hypertensive rats). Methods SHRSP at 7 weeks of age was used daily to ingest approximately 1 g of salt to promote stroke while daily 1,3,3 mg / kg FD was administered intraperitoneally. The changes of SHRSP stroke occurrence, survival time and neurological symptoms after stroke were observed. Results FD could delay the stroke time of SHRSP and prolong the survival time after stroke (P <0.05 or P <0.01). Low dose and middle dose also reduced neurological symptoms after stroke (P <0.05 or P <0.01). Conclusion FD has some anti-stroke effect on SHRSP.