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目的：观察胃窦部幽门螺杆菌感染与胃癌发生的相关关系。方法：应用ＰＣＲ技术对２８ 例胃癌患者的癌组织、癌旁组织、２８ 例慢性胃炎胃窦粘膜及２０ 名正常对照胃粘膜组织中的幽门螺杆菌（ＨＰ）进行了检测，同时应用酶联免疫吸附试验（ＥＬＩＳＡ）测定了上述患者及正常对照粘膜组织中的ＩＬ－ １、ＩＬ－ ８ 及ＴＮＦα活性。结果：慢性胃炎粘膜与胃癌癌旁粘膜组织ＨＰ的阳性率明显高于对照组，而胃癌组织中的ＨＰ检出率明显低于胃癌癌旁粘膜与胃炎粘膜组织（Ｐ＜ ０．０１）；胃癌患者癌灶粘膜组织ＩＬ－ １、ＩＬ－ ８ 活性降低，尤以ＩＬ－ １ 更为明显，ＴＮＦα明显升高，与对照组相比差异显著（Ｐ＜ ０．０１）。结论：ＨＰ感染局部粘膜组织细胞因子变化在胃癌发生中起一定作用
Objective: To observe the relationship between Helicobacter pylori infection and gastric cancer in gastric antrum. METHODS: Helicobacter pylori (HP) in gastric cancer tissues, paracancerous tissues, 28 chronic gastritis antral mucosa and 20 normal control gastric mucosa tissues were detected by PCR in 28 patients with gastric cancer. The adsorption assay (ELISA) measured the activity of IL-1, IL-8 and TNFα in the above-mentioned patients and normal control mucosal tissues. RESULTS: The positive rate of HP in the mucosa of chronic gastritis and adjacent gastric mucosa was significantly higher than that in the control group. The detection rate of HP in gastric cancer tissues was significantly lower than that in adjacent gastric mucosa and gastritis tissues (P < 0.01); The activity of IL-1 and IL-8 in the tumor tissue of the tumor was decreased, especially in IL-1, and the TNFα was significantly increased compared with the control group (P<0.01). Conclusion: The changes of cytokines in mucosal tissues of HP infection may play a role in the development of gastric cancer