目的分析贵阳市手足口病发病特点和流行特征,为制定手足口病的防控策略提供依据。方法用SPSS 13.0统计软件对2012年贵阳市手足口病疫情资料和实验检测结果进行分析。结果 2012年贵阳市共报告手足口病22 541例,发病率为521.20/10万,其中重症530例,死亡病例4例。发病年龄以3岁以下婴幼儿为主,占63.45%(14 304/22 541),死亡病例平均年龄为1.53岁。男女性别比为1.50∶1,发病高峰在5和11月,各县(市、区)均有病例报告,并且发病率较高。结论 2012年该市手足口病流行强度大,病死率较高,有一定的季节性,对3岁以下婴幼儿危害性极大。 Objective To analyze the characteristics and epidemic characteristics of hand-foot-mouth disease in Guiyang, and provide evidence for the prevention and control of hand-foot-mouth disease. Methods SPSS 13.0 statistical software was used to analyze the epidemiological data and experimental results of HFMD in Guiyang in 2012. Results A total of 22 541 HFMD cases were reported in Guiyang in 2012 with a prevalence of 521.20 / 100 000, of which 530 were severe and 4 were fatal. The age of onset was mainly infants under 3 years old, accounting for 63.45% (14 304/22 541). The average age of death was 1.53 years old. The male-to-female sex ratio was 1.50: 1, and the peak incidence was in May and November. Cases were reported in all counties (cities, districts) and the incidence rate was high. Conclusion In 2012, the epidemic intensity of hand, foot and mouth disease in this city is large with a relatively high case fatality rate and a certain seasonality. It is extremely harmful to infants under 3 years of age.