静脉滴注的给药方案静脉滴注时,输入速率保持恒定,称零级过程;而药物从体内消除为一级过程。若药物在体内瞬时平衡,那么药量变化率为■=k_0-Kx(31)式中k■为滴注速率(单位为mg/hr),K 为消除速率常数,经积分,得x=(?)(1-e~(-kt))(32)将x=VC 代入,得函数方程C=■(1-e~(-kt))(33)当t 充分大时,e~(-kt)趋于零,即到达稳态 Intravenous infusion of drug programs intravenous infusion, the input rate remains constant, said the zero-order process; and the elimination of drugs from the body as a process. If the drug is transiently balanced in vivo, then the rate of change of the drug is ■ = k_0-Kx (31) where k ■ is the instillation rate in mg / hr, K is the elimination rate constant, and x = (1-e ~ (-kt)) (32) Substituting x = VC yields the functional equation C = ■ (1-e ~ (-kt)) (33) When t is sufficiently large, kt) tends to zero, that is to reach steady state