先前的研究已发现,把合成的内源性吗啡肽直接注入实验动物脑室,有强止疼作用。Hosobuchi等也发现,在人心室内注射β—内啡肽(B—E)也能产生止疼作用。据此,本文作者想通过实验来证实自鞘内或硬膜外给予人B—E对伴有疼痛的晚期癌症病人的止疼作用和副作用,并评价血浆和脑脊液中的B—E浓度和疼痛缓解之关系。 Previous studies have found that the injection of synthetic endogenous morphine peptide directly into the ventricles of experimental animals has a strong analgesic effect. Hosobuchi et al. also found that intraventricular injection of beta-endorphin (B-E) can also produce analgesic effects. Based on this, the authors of this article would like to demonstrate through experiments the analgesic and side effects of intrathecal or epidural administration of human B-E to advanced cancer patients with pain, and to evaluate the B-E concentration and pain in plasma and cerebrospinal fluid. Mitigating relationship.