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目的:探讨急性一氧化碳中毒(ACOP)患者血清中内皮索(ET)、一氧化氮(NO)水平的变化及意义。方法:选择不同中毒程度的ACOP患者75例.于入院即刻抽血,分别测定血中ET、NO浓度;选健康对照组25例。结果:中、重度ACOP患者血清ET水平明显高于正常健康对照组及轻度中毒组;轻度中毒组与正常对照组比较差异不明显(P>0.05),轻度与中度中毒组比较差异有显著性(P<0.05),中度与重度中毒组比较,ET水平均升高,但两者差异不具有统汁学意义(P>0.05):NO的变化与之相反。ET与NO之间存在负相关关系(r=0.606.P<0.05)。结论:ACOP时NO水平降低,ET水平升高,NO ET比例失调,加重微血管痉挛,加重组织缺血缺氧,在ACOP病理过程中起着重要作用。
Objective: To investigate the changes and significance of serum endothelin (ET) and nitric oxide (NO) levels in patients with acute carbon monoxide poisoning (ACOP). Methods: 75 cases of ACOP patients with different degrees of poisoning were selected, blood was drawn immediately after admission, and the concentrations of ET and NO in the blood were measured respectively; 25 healthy control subjects were selected. Results: The level of serum ET in moderate and severe ACOP patients was significantly higher than that in normal control group and mild poisoning group. There was no significant difference between mild poisoning group and normal control group (P> 0.05), mild and moderate poisoning group (P <0.05). Compared with the moderate and severe poisoning groups, the levels of ET increased. However, the differences between the two groups were not statistically significant (P> 0.05). The changes of NO were the opposite. There was a negative correlation between ET and NO (r = 0.606, P <0.05). CONCLUSION: The decrease of NO level, the increase of ET level, the imbalance of NO ET, the increase of microvascular spasm and the increase of tissue ischemia and hypoxia in ACOP play an important role in the pathogenesis of ACOP.