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目的:探讨Survivin及Anx-A1在肝癌组织中的表达及其临床意义。方法:收集原发性肝癌病例45例,采用免疫组织化染色法检测Survivin及Anx-A1在肝癌组织及癌旁正常组织中的表达,分析Survivin及Anx-A1的表达与肝癌临床病理特征的关系。结果:Survivin在肝癌组织中的阳性表达率为86.67%,在癌旁正常组织中的阳性表达率为17.78%;Anx-A1在肝癌组织中的阳性表达率为46.67%,在癌旁正常组织中的阳性表达率为8.89%;Survivin及Anx-A1在肝癌组织中的阳性表达率均显著高于癌旁正常组织,差异具有统计学意义(P<0.05);不同肿瘤分级患者肝癌组织中Survivin与Anx-A1的表达水平存在显著差异(P<0.01),肿瘤分级越高,Survivin与Anx-A1表达水平越高。结论:Survivin及Anx-A1的表达与肝癌的发生发展密切相关,可用于肝癌的辅助诊断。
Objective: To investigate the expression and clinical significance of Survivin and Anx-A1 in hepatocellular carcinoma. METHODS: Forty-five cases of primary liver cancer were collected. The expression of Survivin and Anx-A1 in hepatocellular carcinoma tissues and adjacent normal tissues were detected by immunohistochemical staining. The relationship between the expression of Survivin and Anx-A1 and clinicopathological features of hepatocellular carcinoma was analyzed. . Results: The positive expression rate of survivin was 86.67% in hepatocellular carcinoma, 17.78% in normal tissue adjacent to cancer, and the positive rate of Anx-A1 was 46.67% in hepatocellular carcinoma. The positive expression rate of Survivin and Anx-A1 was significantly higher than that of normal tissue adjacent to cancer (P<0.05). The expression of Survivin in liver cancer tissues of patients with different tumor grades was significantly higher than that of adjacent tissues. There was a significant difference in the expression level of Anx-A1 (P<0.01). The higher the tumor grade, the higher the expression level of Survivin and Anx-A1. Conclusion: The expression of Survivin and Anx-A1 is closely related to the occurrence and development of hepatocellular carcinoma. It can be used for the diagnosis of liver cancer.