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用X射线衍射法对那格列奈的多晶型结构进行了测定,并进行了动物模拟降血糖试验.结果表明:那格列奈具有B晶型、H晶型和S晶型三种结构.H晶型为三斜晶系,晶胞参数a=1.769 9(7)nm,b=2.719 1(8)nm,c=1.267 0(6)nm,α=61.75(3)°,β=73.11(6)°,γ=66.77(7)°,V=4.895 nm3,Z=10.S晶型为正交晶系,晶胞参数a=2.317 8(6)nm,b=2.533 2(5)nm,c=0.653 1(2)nm,α=β=γ=90°,V=3.835 nm3,Z=8.小白鼠模拟降糖试验表明:与目前上市的H晶型相同,S晶型也具有很好的降血糖作用,特别是在用药40 m in时,效果更显著.
The polymorphism of nateglinide was determined by X-ray diffractometry and the hypoglycemic test of animal model was carried out.The results showed that nateglinide has three crystal structures of B crystal form, H crystal form and S crystal form .H crystal form is triclinic with a = 1.769 9 (7) nm, b = 2.719 1 (8) nm, c = 1.267 0 The lattice constants are as follows: a = 2.317 8 (6) nm, b = 2.533 2 (5) ) nm, c = 0.653 1 (2) nm, α = β = γ = 90 °, V = 3.835 nm3, Z = 8. The simulated hypoglycemic experiments in mice showed that, Also has a good hypoglycemic effect, especially in medication 40 m in, the effect is more pronounced.