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目的研究nm~(23)基因产物/NDPK在喉癌中表达的临床意义。方法行全喉切除术的94例喉鳞状细胞癌的石蜡标本,采用抗nm~(23)-H1基因产物╱NDPK单克隆抗体进行免疫组织化学ABC法染色。结果 nm~(23)/NDPK在喉鳞状细胞癌中的阳性率为45.7%(43/94),nm~(23)╱NDPK在喉癌伴颈淋巴结转移和无颈淋巴结转移组织中的阳性率分别为33.3%(14/42)和55.8%(29/52),经卡方检验,P<0.05,两组间nm~(23)/NDPK阳性率存在显著性差异。结论结合临床和病理资料进行分析,结果显示nm~(23)/NDPK表达与喉癌分期、细胞的病理分级、肿瘤大小和术后3年生存率均无关;与喉癌颈淋巴结转移呈负相关,对预测喉癌颈淋巴结转移有一定的参考价值。
Objective To study the clinical significance of the expression of nm23 gene product / NDPK in laryngeal carcinoma. Methods Paraffin sections of 94 laryngeal squamous cell carcinomas with total laryngectomy were stained immunohistochemically with anti-nm23-H1 gene product / NDPK monoclonal antibody. Results The positive rate of nm23 / NDPK in laryngeal squamous cell carcinoma was 45.7% (43/94). The positive rate of nm23 / NDPK in laryngeal carcinoma with cervical lymph node metastasis and cervical lymph node metastasis The rates were 33.3% (14/42) and 55.8% (29/52) respectively. There was significant difference between the two groups in the positive rate of nm23 / NDPK by chi square test (P <0.05). Conclusions Combined with clinical and pathological data, the expression of nm23 / NDPK has no correlation with the stage of laryngeal carcinoma, the pathological grade of tumor, the size of tumor and the 3-year survival rate after operation, but negatively correlated with the metastasis of cervical lymph node , Which has certain reference value for predicting cervical lymph node metastasis of laryngeal carcinoma.