勒雪氏病是一种婴幼儿急性弥漫性组织细胞增生症,皮疹印片及末梢血涂片同时出现较多的组织细胞,甚为罕见,笔者于1993年3月遇见1例。 患儿,女,4个月,以贫血、出血性皮诊、咳嗽、发热等症状就诊,疑溶贫入院。体检:T38℃,P130次/分,R36次/分,体重7kg,发育正常,营养中等,神情较烦躁,皮肤苍白,重度贫血貌,脸部、躯干及手足心处均有对称散在及密布皮诊,呈暗红色细小斑丘疹,压之色不退,颈、腹股沟皮肤皱折处褶烂,腋下及腹股沟扪及花生米大小淋巴结1～2个,质中,表面光滑,无粘连,可活动,无触痛,耳道脂溢性皮炎结痴痕,颈软,双肺呼吸音粗,心尖区二级收缩期杂音,心率160次/分,腹膨隆,肝肋下4cm,质中,缘钝,脾肋下8cm,质较硬,无压痛。B超显示肝脾肿大,以脾大为著,陶片头颅片无明显异常。实验室检查:Hb 58g/L,RBC Leser’s disease is an infantile acute diffuse histiocytosis, rash prints and peripheral blood smear at the same time there are more tissue cells, very rare, the author met in March 1993 in 1 case. Children, women, 4 months to anemia, hemorrhagic skin examination, cough, fever and other symptoms of treatment, suspected dissolved poor admission to hospital. Physical examination: T38 ℃, P130 beats / min, R36 beats / min, weight 7kg, normal development, moderate nutrition, look more irritable, pale skin, severe anemia appearance, face, The diagnosis was dark red rash, the pressure of the color is not refundable, neck, groin skin fold folds, armpits and groin palpable peanut-sized lymph nodes 1 to 2, the quality of the surface smooth, no adhesions, can be Activities, no tenderness, ear seborrheic dermatitis knot marks, neck soft, lung breath sounds crude, apical systolic murmur, heart rate 160 beats / min, abdominal bulging, liver ribs 4cm, Edge blunt, spleen ribs 8cm, the quality of hard, no tenderness. B-show hepatosplenomegaly, with splenomegaly, pottery cranial no obvious abnormalities. Laboratory tests: Hb 58g / L, RBC