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向大鼠杏仁基底内侧核（ＢＭＡ）内微量注射八肽胆囊收缩素（ＣＣＫ－８）、ＣＣＫ受体阻断剂（Ａ型或Ｂ型），进行胃内压和胃运动的记录和分析。结果如下：ＣＣＫ－８（５０ｎｇ／１μｌ）注射后胃内压（ＩＧＰ）和胃蠕动频率（ＧＭＦ）显著下降（Ｐ＜０．０１）；单独微量注射ＣＣＫ－Ａ受体阻断剂Ｌ３６４７１８（１００ｎｇ／１μｌ）或ＣＣＫ－Ｂ受体阻断剂Ｌ３６５２６０（１００ｎｇ／１μｌ），对胃内压和胃运动无明显影响；先给Ｌ３６４７１８（１００ｎｇ／１μｌ）再给予ＣＣＫ－８，则ＩＧＰ，ＧＭＦ的抑制不再出现；先给Ｌ３６５２６０则ＣＣＫ－８对ＩＧＰ和ＧＭＦ的抑制仍出现；在ＢＭＡ附近，如终纹连合部（ＢＳＴＩＡ）和杏仁皮质核（ＰＬＣｏ）内注射ＣＣＫ－８均不出现胃内压、胃运动的抑制作用。提示，ＢＭＡ内ＣＣＫ－８对胃运动、胃内压有抑制作用，这种抑制作用与ＢＭＡ内的ＣＣＫ－Ａ受体有关，而ＣＣＫ－Ｂ受体可能不参加此抑制作用。
Microinjection of octapeptide cholecystokinin (CCK-8) and CCK receptor blockers (type A or type B) into the basilar medial nucleus (BMA) of rats was performed to record and analyze gastric pressure and gastric motility. The results were as follows: The intragastric pressure (IGP) and gastric motility frequency (GMF) were significantly decreased after CCK-8 injection (50ng / 1μl) (P <0.01) / 1μl) or CCK-B receptor antagonist L365260 (100ng / 1μl) had no significant effect on gastric pressure and gastric motility. Suppression of IGP and GMF by first administering L364718 (100ng / 1μl) to CCK- The inhibition of IGP and GMF by CCK-8 still occurred after L365260 was given first. In the vicinity of BMA, CCK-8 did not appear in the stomach when injected into BSTIA and PLCo Pressure, gastric motility inhibition. These results suggest that CCK-8 in BMA has inhibitory effect on gastric motility and gastric pressure. This inhibitory effect is related to CCK-A receptor in BMA, while CCK-B receptor may not participate in this inhibitory effect.