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本文介绍了抗忧虑镇静剂氯羟安定(L)经静注、肌注、口服与舌下给药后血药浓度以及动力学参数的比较。实验由健康受试者10人,按五种要求,随机、交叉设计给药,剂量为每人2毫克的L,两次给药至少间隔一周。给药方法如下:A,静注L1毫升(2毫克/毫升),30秒钟内于肘前静脉输毕;B,肌注L1毫升(2毫克/毫升),于三角肌注射;C,口服L体外溶出速率1小时为80％的标准片(1毫克/片)二片,用100～200毫升水送服;D,舌下给予L标准片(1毫克/片)二片,保持15分钟;E,舌下L给予溶出速率1小时为84％的特殊片(1毫克/片)二片,保持15分钟。 A、B组受试者饮食不受限制,C、D和E
This article describes the anti-anxiety sedatives chlorhexidine (L) by intravenous, intramuscular, oral and sublingual administration of plasma concentration and kinetic parameters comparison. The experiment consisted of 10 healthy subjects, randomized, crossover designed for five requirements at a dose of 2 mg / person L and administered twice at least one week apart. A, intravenous injection of L1 ml (2 mg / ml), 30 seconds before the completion of the elbow vein was completed; B, intramuscular injection of L1 ml (2 mg / ml) in the deltoid injection; C, oral L in vitro dissolution rate 1 hour 80% of the standard tablets (1 mg / tablet) two, with 100 to 200 ml of water delivery; D, sublingual L standard tablets (1 mg / tablet) two, hold for 15 minutes ; E, sublingual L given to the dissolution rate of 84% for 1 hour special tablets (1 mg / tablet) two, for 15 minutes. A, B group subjects diet is not limited, C, D and E.