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体外研究显示，溴氰菊酯（１ｘ１０￣（－７）～１ｘ１０￣（－４）ｍｏｌ／Ｌ）可使大鼠大脑皮层和海马突触小体￣３Ｈ－ＤＬ－谷氨酸摄取量分别降低７．２％～２１．５％和１０．４％～２５．１％，且存在明显的剂量。效应关系。而氯菊酯却只在高剂量（１ｘ１０￣（－４）ｍｏｌ／Ｌ）方使海马突触小体￣３Ｈ－ＤＬ－谷氨酸摄取明显降低。此外，溴氰菊酯还可降低小脑和纹状体￣３Ｈ－ＤＬ－谷氨酸的摄取，抑制率分别为１６．５％和３１．８％。结果表明，溴氰菊酯和氯菊酯可严重干扰脑组织高亲和性谷氨酸摄取机制的功能，其中以含氰基的溴氰菊酯作用较强，因此在拟除虫菊酯杀虫剂对哺乳动物的中枢兴奋性毒性作用中可能具有重要意义。
In vitro studies showed that deltamethrin (1x10 ~ (-7) ~1 × 10 ~ (-4) mol / L) decreased the amount of 3H-DL-glutamate uptake in synaptosomes of cerebral cortex and hippocampus 7.2% ~ 21.5% and 10.4% ~ 25.1%, and there is a clear dose. Effect relationship. Permethrin decreased the uptake of 3H-DL-glutamate in hippocampal synaptosomes only at high dose (1x10 ~ (-4) mol / L). In addition, deltamethrin could also reduce uptake of 3H-DL-glutamate in the cerebellum and striatum, with rates of inhibition of 16.5% and 31.8%, respectively. The results showed that deltamethrin and permethrin could seriously interfere with the function of high-affinity glutamate uptake mechanism of brain tissue, of which cyanogen-containing deltamethrin was strong, so pyrethroid insecticides It may have important implications for mammalian central excitotoxicity.