论文部分内容阅读
目的探讨变应性疾病(包括支气管哮喘和变应性鼻炎)患儿常见的变应原与血清尘螨特异性IgE(sIgE)和IgG4水平的关系。方法对310例4～13岁变应性疾病儿童进行12种常见变应原皮肤点刺试验,同期采用夹心ELISA方法检测血清尘螨sIgE和IgG4水平。采用SPSS13.0软件进行统计学分析。结果变应性疾病儿童皮肤变应原检测阳性100%(310/310例),≥3种变应原阳性者占35.8%(111/310例)。引起变应性疾病的变应原主要为吸入物,阳性率最高的变应原是粉尘螨。变应性疾病儿童血清尘螨sIgE和IgG4水平明显高于健康对照组(t=14.253、12.314,Pa<0.01)。血清尘螨sIgE水平与皮肤变应原试验阳性种类的多少无相关性(r=-0.004 3,P>0.05);粉尘螨变应原阳性强度与血清尘螨sIgE水平呈正相关(r=0.219 8,P<0.05);血清尘螨sIgE水平与IgG4水平呈一定正相关(r=0.173 0,P<0.05)。结论变应原皮肤点刺试验有助于发现变应性疾病儿童的变应原及了解机体免疫状态强度,提供应尽可能避免接触的变应原,有条件者可进行脱敏治疗。监测血清sIgE和IgG4水平对儿童变应性疾病临床治疗有指导意义。
Objective To investigate the relationship between allergens and serum specific mite-specific IgE (sIgE) and IgG4 levels in children with allergic diseases (including bronchial asthma and allergic rhinitis). Methods Twelve common allergens skin prick tests were performed on 310 children aged 4-13 years with allergic diseases. Serum dust mite sIgE and IgG4 levels were detected by sandwich ELISA during the same period. SPSS13.0 software was used for statistical analysis. Results The allergens were detected in 100% (310/310) cases of allergic diseases and 35.8% (111/310 cases) in ≥3 allergens. Allergens that cause allergic disease are mainly inhalers, and the highest positive allergen is dust mite. Serum dust mite sIgE and IgG4 levels in children with allergic diseases were significantly higher than those in healthy controls (t = 14.253, 12.314, Pa <0.01). There was no correlation between sIgE level of serum dust mite and the positive skin allergen test (r = -0.004 3, P> 0.05). The positive intensity of dust mite allergen was positively correlated with sIgE level of serum dust mite (r = 0.219 8 , P <0.05). The sIgE level of serum dust mite had a positive correlation with the level of IgG4 (r = 0.173 0, P <0.05). Conclusions Allergen skin prick test is helpful to find allergens in children with allergic diseases and to understand the intensity of immune status, to provide allergens that should be avoided as much as possible, and to treat with desensitization if necessary. Monitoring serum sIgE and IgG4 levels in children with allergic disease clinical treatment has instructive significance.