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目的:探讨艾灸神阙穴对不同程度力竭运动大鼠抗疲劳性运动作用的影响.方法:将72只 SD雄性大鼠随机分为空白组(8只)、模型组(32只)和艾灸组(32只).模型组和艾灸组又按游泳次数不同分为4个亚组,即1次组、4次组、7次组、10次组,每组8只.除空白组外,采用游泳实验制造反复力竭模型.艾灸组大鼠每次力竭运动后,施温和灸神阙穴15 min,隔日1次.采用全自动分析仪检测力竭运动24 h后血清中葡萄糖(GLU)、丙二醛(MDA)、血尿素氮(BUN)浓度及天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、乳酸脱氢酶(LDH)活性.结果:模型大鼠力竭时间先长后短,模型4次组大鼠力竭时间明显长于1次组(P＜0.01),模型7、10次组大鼠力竭时间明显短于1次组(均P＜0.01),艾灸7次、10次组大鼠力竭时间均明显长于同次模型组(均P＜0.01).模型7次、10次组大鼠血清GLU含量均较同次空白组升高(均P＜0.01),模型4次、7次、10次组大鼠血清MDA、BNU含量及AST、ALT、LDH活性均较同次空白组升高(P＜().05,P＜0.01);艾灸7次、10次组大鼠血清GLU、MDA、BNU含量及AST、ALT活性均较同次模型组下降(P＜0.05,P＜0.01),艾灸4次、7次、10次组大鼠血清LDH活性均较同次模型组下降(P＜0.05,P＜0.01).结论:艾灸神阙穴可以降低长期疲劳大鼠机体血清MDA、BNU含量及AST、ALT、LDH活性,有效改善大鼠长期疲劳症状,为今后临床应用艾灸神阙穴抗运动性疲劳提供了一定的实验基础.“,”Objective To explore the effect of moxibustion at Shénquè(神阙 CV 8) on the anti-exercise-induced fatigue in rats after exhaustive exercise in varying degrees.Methods Seventy-two SD rats were randomly divided into 3 groups according to the random number table method,including blank group,model group and moxibust-ion group.The model group and moxibustion group were divided into 4 subgroups respectively,that was 1 time,4 times,7 times and 10 times subgroup.There were 9 groups with 8 rats in each group.Except blank group,all the rats were established into exhaustive models through swimming.Mild moxibustion at CV 8 was carried out for 15 min in the rats in moxibust-ion group after modeling for once every other day.The concentration of serum glucose (GLU),malonaldehyde (MDA) and blood urea nitrogen (BUN) as well as the activity of aspartate transaminase (AST),alanine transaminase (ALT) and lactic dehydrogenase (LDH) were detected 24h after the exhaustive exercise by adopting full-automatic analyzer.Results The exhaustive time of rats were long at first but shorter later.The exhaustive time of rats in the model group (4 times) were obviously longer than that in the model group (1 time) (P＜0.01),the exhaustive time of rats in the model group (7 times) and model group (10 times) were obviously shorter than that in the model group (1 time) (P＜0.01),and the exhaustive time of rats in the moxibustion group (7 times) and moxibustion group (10 times) were obviously longer than that in the model group with the same number of times (P＜0.01),the serum GLU level of rats in the model group (7 times) and model group (10 times) increased when compared with the blank group (P＜0.01),and the serum MDA and BNU levels as well as the activity of AST,ALT and LDH of rats in the model group (4 times),model group (7 times) and model group (10 times) increased when compared with the blank group (P＜0.05 or P＜0.01),the serum GLU,MDA and BNU levels as well as the activity of AST and ALT of rats in the moxibustion group (7 times) and moxibustion group (10 times) reduced when compared with the model group with the same number of times (P＜0.05 or P＜0.01),and the serum LDH activity of rats in the moxibustion group (4 times),moxibustion group (7 times) and moxibustion group (10 times) reduced when compared with the model group with the same number of times (P＜0.05 or P＜0.01).Conclusion Moxibust-ion at CV 8 can reduce the serum MDA and BNU levels as well as the activity of AST,ALT and LDH of organism in a status of long-term fatigue,effectively improve the symptom of long-term fatigue,providing a certain experimental basis for the clinical application of moxibustion at CV 8 in the process of ant-i-exercise-induced fatigue in the future.