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本实验观察了低分子右旋糖酐或生理盐水等容血液稀释对家兔急性心肌缺血/再灌注损伤的影响。结果表明:两种溶液稀释血液均可降低缺血心肌再灌时全血粘度,但右旋糖酐等容血液稀释对降低缺血心肌再灌后心肌组织脂质过氧化物及保护心肌超氧化物歧化酶活性的效应明显高于生理盐水等容稀释。此外右旋糖酐等容血液稀释尚可改善缺血心肌再灌后心功能及控制梗塞灶的扩大。结果提示:低分子右旋糖酐等容血液稀释具有一定程度的抗再灌损伤效应,其机理似与降低血液粘滞性改善微循环及抗氧自由基的作用有关。
This experiment observed the effects of low molecular weight dextran or saline isovolumetric hemodilution on acute myocardial ischemia/reperfusion injury in rabbits. The results showed that the two solutions diluted blood can reduce the whole blood viscosity when ischemic myocardium is reperfused, but dextran normovolemic hemodilution reduces myocardial lipid peroxidation and protects myocardial superoxide dismutase after ischemia The effect of activity is significantly higher than that of saline isotonic dilution. In addition, dextran isovolumetric hemodilution can improve cardiac function after ischemic reperfusion and control the expansion of infarct foci. The results suggest that low molecular weight dextran isovolumic hemodilution has a certain degree of anti-reperfusion injury effects, and its mechanism appears to be related to the reduction of blood viscosity and improve the microcirculation and the role of antioxidant free radicals.