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临床上在对肾移植患者进行环孢霉素A(CsA)血药浓度曲线测定时常可发现 ,患者早、晚服用相同剂量的CsA ,但晨间谷值浓度往往高于傍晚谷值浓度 ,有时甚至可相差一倍。这种现象会对肾移植患者的病情预后产生什么影响 ?对进一步合理服用CsA有何意义 ?为此我们回顾性进行
Clinically in renal transplant patients cyclosporine A (CsA) plasma concentration curve often found that patients take the same dose of morning and evening CsA, but the morning trough concentration is often higher than the evening trough concentration, and sometimes Even a difference of double. What is the effect of this phenomenon on the prognosis of patients with renal transplant? What is the significance of further rational use of CsA? For this reason we retrospectively