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为探讨缺血对硬变肝脏的损害及激素对温缺血硬变肝脏肝细胞的作用，对２０例合并肝硬化的肝细胞癌病人进行前瞻性临床对照研究。采用Ｐｒｉｎｇｌｅ＇ｓ法行肝切除１４例，其中６例阻断入肝血流前静注地塞米松，肝缺血时间７～１６ｍｉｎ；另６例未阻断血流作对照。通过肝功能、肝组织ＡＴＰ含量和肝细胞超微结构观察，证明Ｐｒｉｎｇｌｅ＇ｓ法入肝血流阻断在硬变肝脏行肝切除时是利多弊少的，但并非所有切肝病例都需要。每次阻断肝血流在１６ｍｉｎ内一般是安全的。地塞米松对温缺血硬变肝脏肝细胞具有保护作用。
To investigate the effects of ischemia on hardened liver and the effects of hormones on hepatic cells in warm ischemia and hepatic ischemia, a prospective clinical controlled study was conducted on 20 cases of hepatocellular carcinoma with cirrhosis. Pringle’s method was adopted for hepatectomy in 14 cases, of which 6 cases were blocked with dexamethasone before hepatic blood flow, and hepatic ischemia time was 7-16 min. The other 6 cases were not blocked blood flow as a control. Through liver function, liver tissue ATP content and ultrastructure observation of liver cells, it was proved that Pringle’s liver blood flow blockade was more beneficial and less effective in hepatic resection of hard metastatic liver, but not all cases of liver resection are needed. It is generally safe to block liver blood flow every 16 minutes. Dexamethasone has protective effects on warm ischemic and hepatic hepatocytes.