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目的研究嗜酸性垂体腺瘤与发生在垂体的瘤样细胞瘤的组织病理学及超微结构特点。方法对2000~2004年15例诊断为垂体腺瘤的标本进行常规HE染色与免疫组织化学和电子显微镜观察。结果15例病例中,生长激素(GH)腺瘤10例;GH与促乳激素(PRL)混合性腺瘤3例;另外2例GH与PRL表现为阴性,电镜观察细胞内充满异常的线粒体,临床无内分泌症状为瘤样细胞瘤。结论临床表现、免疫组织化学染色及电子显微镜检查是鉴别诊断嗜酸性垂体腺瘤与发生在垂体的瘤样细胞瘤的重要依据。
Objective To study the histopathological and ultrastructural features of eosinophilic pituitary adenomas and tumor-like tumors in the pituitary gland. Methods 15 cases of pituitary adenoma diagnosed from 2000 to 2004 were examined by HE staining, immunohistochemistry and electron microscopy. Results Among the 15 cases, 10 cases of GH adenoma, 3 cases of mixed adenoma of GH and prolactin (PRL), 2 cases of GH and PRL were negative, the cells were filled with abnormal mitochondria under electron microscope, No endocrine symptoms for tumor-like cell tumor. Conclusions Clinical manifestations, immunohistochemical staining and electron microscopy are important basis for the differential diagnosis of eosinophilic pituitary adenoma and tumor-like tumor occurring in the pituitary.