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本文报告40例复发性口疮(ROU)患者,均用低分子猪胸腺素治疗,治疗后3～12月复查,有效率为95%。全部患者均检测血清免疫球蛋白(IgA,IgG、IgM),总补体(CH50),补体3(C3)循环免疫复合物(CIC)以及淋巴母细胞转挟率(LTT),E—玫瑰花结形成率(ERFT)。结果表明,ROU 患者的 IgA、IgG、IgM 均明显高于健康人对照组,而 LTT,ERFT 明显低于对照组(P<0.01)。但治疗后的体液免疫指标与细胞免疫指标均无明显变化,而免疫指标的变化与临床疗效也不相关。本研究的结果说明 ROU 患者的细胞免疫功能低于健康人,用胸腺素治疗有效、安全、价廉。并建议ROU 患者治疗前可免去上述几种免疫学检测。
This article reports 40 cases of recurrent aphthous (ROU) patients were treated with low molecular weight porcine thymosin, 3 to 12 months after treatment review, the effective rate was 95%. All patients were tested for serum immunoglobulin (IgA, IgG, IgM), total complement (CH50), complement 3 (CIC) circulating immune complex (CIC) and lymphoblast mesenchymal transition (LTT) Forming rate (ERFT). The results showed that the serum levels of IgA, IgG and IgM in patients with ROU were significantly higher than those in healthy controls, while the levels of LTT and ERFT were significantly lower than those in the control group (P <0.01). However, no significant changes were observed in humoral immune index and cellular immune index after treatment, but the changes in immune index were not related to clinical efficacy. The results of this study show that patients with ROU cellular immune function is lower than healthy people, with thymosin treatment effective, safe and inexpensive. And recommended ROU patients before treatment can be exempt from the above several immunological tests.