论文部分内容阅读
本实验为了探讨无机砷化物经口给毒对动物的致畸胎性,受试物为三氧化二砷(As_2O_3)和砷酸三钠(Na_3AsO_4·12H_2O),实验动物为性成熟Wister太白鼠,经雌雄同笼交配后,将确定受孕之雌鼠随机分组。三氧化二砷试验设20、10、0.1mg/kg三个剂量组,每组孕鼠7-12只。砷酸三钠试验设100、50、25mg/kg三个剂量组,每组孕鼠5-6只。同时设阴性对照组(给蒸馏水),阳性对照组(给敌桔双1mg/kg),受试物均用蒸
In order to study the teratogenicity of the animal ants caused by oral administration of inorganic arsenic compounds, the test substance is As2O3 (arsenic trioxide) and sodium arsenate (Na3AsO412H2O). The experimental animals are sexually mature Wister rats, After mating, the female mice that were conceived were randomly assigned. Arsenic trioxide test set 20,10,0.1 mg / kg three dose groups, each group of 7-12 pregnant rats. Arsenic trioxide test set 100,50,25 mg / kg three dose groups, each 5-6 pregnant rats. At the same time set negative control group (to distilled water), positive control group (to the enemy orange double 1mg / kg), the test substance is steamed