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目的了解无锡市锡山区体检人员HBsAg携带情况,结合丙氨酸转氨酶(ALT)及HBeAg分析,探讨HBV感染者与肝功能异常的相关性。方法采用酶联免疫吸附试验(ELISA)法检测HBsAg,对其中部分阳性者进行HBeAg检测,同时用全自动生化分析仪检测血清中ALT。结果2006—2008年92349名体检人员,HBsAg携带率为3.47%,有呈逐年下降的趋势,各年度间差异有统计学意义(χ2=8.046,P<0.05);其中1452例HBsAg阳性者中HBeAg阳性的人员ALT异常率为31.79%,与HBeAg阴性人员的ALT异常率14.10%之间差异有统计学意义(χ2=51.37,P<0.01)。结论要加强宣传乙型肝炎相关防护知识,对HBsAg阳性者应做乙肝标志物并结合肝功能(ALT)来判断其病情和传染性。
Objective To understand the status of HBsAg carrier in Xishan District of Wuxi City, and to explore the relationship between HBV infection and liver dysfunction by alanine aminotransferase (ALT) and HBeAg analysis. Methods HBsAg was detected by enzyme-linked immunosorbent assay (ELISA), HBeAg was detected in some of them, and serum ALT was detected by automatic biochemical analyzer. Results Among 92349 medical staff from 2006 to 2008, the carrying rate of HBsAg was 3.47%, showing a trend of declining year by year with a significant difference between the years (χ2 = 8.046, P <0.05). Of the 1452 HBsAg positive cases, HBeAg The positive rate of abnormal ALT was 31.79%, which was significantly different from that of negative HBeAg negative individuals (14.10%) (χ2 = 51.37, P <0.01). Conclusion It is necessary to strengthen the publicity of hepatitis B-related protective knowledge, and HBsAg-positive patients should be treated with hepatitis B markers combined with liver function (ALT) to determine their condition and infectiousness.