【摘 要】
：
目的 观察加味六安煎对咳嗽变异性哮喘(CVA)大鼠气道炎症及肺组织气道重塑病理变化的影响,探讨加味六安煎治疗咳嗽变异性哮喘的作用机制.方法 将60只Wistar大鼠随机分为正常
【机 构】
：
北京中医药大学 北京100029北京中医药大学东方医院;
论文部分内容阅读
目的 观察加味六安煎对咳嗽变异性哮喘(CVA)大鼠气道炎症及肺组织气道重塑病理变化的影响,探讨加味六安煎治疗咳嗽变异性哮喘的作用机制.方法 将60只Wistar大鼠随机分为正常组、模型组、孟鲁司特钠组、加味六安煎(低、中、高)剂量组.以卵蛋白、氢氧化铝致敏并吸入卵蛋白激发法复制咳嗽变异性哮喘大鼠模型,观察各组大鼠肺组织的炎性细胞浸润、胶原沉积(胶原面积及胶原容积分数)程度以及气道形态学参数的变化.结果 与正常组相比,模型组镜下可见肺组织炎性细胞浸润、充血、水肿;与模型组相比,各治疗组肺组织炎性细胞减少,充血、水肿程度减轻;与正常组相比,模型组胶原面积增加(P<0.05),各治疗组间相比,加味六安煎高剂量组胶原面积减少最明显(P0.05);与正常间组相比,模型组胶原容积分数增加(P<0.05),各治疗组间相比,加味六安煎高剂量组胶原容积分数降低最明显(P0.05);与正常组相比,模型组平滑肌面积/支气管基底膜周径(Wam/Pbm)、气管内壁面积/支气管基底膜周径(Wai/Pbm)均明显增大(P<0.05),各治疗组间相比,加味六安煎高剂量组Wam/Pbm、Wai/Pbm比值均为最小(P0.05).结论 加味六安煎治疗咳嗽变异性哮喘的可能作用机制之一是通过减轻肺组织炎性细胞浸润、充血、水肿程度,减少气道周围胶原沉积,干预咳嗽变异性哮喘大鼠气道重塑,从而达到防治本病的目的.
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