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为探讨米索前列醇用于晚期妊娠引产的效果及安全性 ,采用随机对照研究的方法对 2 85例足月孕妇 (孕周 38～ 42 )进行观察研究 ,米索前列醇组 140例 ,用 2 5μg米索前列醇 (以下简称米索 )阴道后穹隆上药 ;对照组 145例 ,催产素静脉滴注引产。结果 :米索引产组 (实验组 )引产成功率 97.14% ,明显高于对照组 82 .75 % (P<0 .0 5 ) ;实验组诱导产兆时间及总产程的时间明显短于应用催产素的对照组 ,差异有统计学意义 (P<0 .0 1)。两组的胎儿、新生儿情况、产后出血、产道撕伤、产后感染均无显著性差异。结论 :2 5μg米索阴道用药用于晚期妊娠引产的方法简单、可靠、安全 ,值得推广。
To investigate the efficacy and safety of misoprostol for induction of labor during late pregnancy, a randomized controlled study was conducted on 285 full-term pregnant women (gestational age 38 to 42). Misoprostol group 2 5μg misoprostol (hereinafter referred to as misoprostol) vaginal posterior fornix; control group of 145 cases, intravenous oxytocin induction of labor. Results: Misoprostol induction group (experimental group) induction of labor success rate was 97.14%, significantly higher than the control group 82.75% (P <0. 05); experimental group induced omens and time of labor was significantly shorter than the application of oxytocin The control group, the difference was statistically significant (P <0.01). There were no significant differences between the two groups in fetus, newborn, postpartum hemorrhage, birth canal laceration and postpartum infection. Conclusion: The method of vaginal administration of 25 μg misoprostol for induction of labor during late pregnancy is simple, reliable and safe and worth promoting.