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目的:探讨感染白假丝酵母菌及非白假丝酵母菌的早产儿危险因素及伴发疾病的不同,为早期给予针对性的预防及治疗奠定基础。方法:选取2009年1月1日~2011年12月31日期间于长春市妇产医院确诊为侵袭性真菌感染的早产儿,根据血液或尿培养的结果分为感染白假丝酵母菌和非白假丝酵母菌组,分析两组之间的危险因素。结果:104例确诊的真菌感染的早产儿中,54例感染白假丝酵母菌,50例感染非白假丝酵母菌。感染白假丝酵母菌及非白假丝酵母菌发生率分别为1.53%及1.42%,病死率为18.51%及34.00%,无统计学差异(P>0.05)。单因素分析提示,胎龄、发病月份、巨细胞病毒感染统计学相关性(P<0.05)。结论:胎龄≥34周及秋冬季时易感染非白假丝酵母菌,CMV感染及春夏季节易感染白假丝酵母菌。
Objective: To investigate the risk factors and concomitant diseases in preterm infants infected with Candida albicans and non-Candida albicans and to lay the foundation for targeted prevention and treatment in the early stage. Methods: Preterm infants diagnosed as invasive fungal infection in Changchun Maternity Hospital from January 1, 2009 to December 31, 2011 were selected and divided into two groups according to the result of blood or urine culture: Candida albicans group, the risk factors were analyzed between the two groups. Results: Of the 104 confirmed fungal-infected preterm infants, 54 were infected with Candida albicans and 50 were infected with non-Candida albicans. The incidences of Candida albicans and Candida albicans were 1.53% and 1.42%, respectively. The case fatality rates were 18.51% and 34.00%, respectively, with no significant difference (P> 0.05). Univariate analysis showed that gestational age, onset of the month, cytomegalovirus infection was statistically significant (P <0.05). CONCLUSION: Non-Candida albicans is easily infected in gestational age ≥34 weeks and autumn and winter, CMV infection and susceptible to Candida albicans in spring and summer.