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人工合成拟除虫菊二氯苯醚菊酯是一种优良杀虫剂。我们用~(14)C-二氯苯醚菊酯(Permethrin)经气管注入大鼠肺部后,另以灌胃给药法作为对照,进行毒物动力学方面的研究。血毒物浓度一时间曲线,符合一级速率两室开放模型。自气管注入后的一级吸收速率常数Ka0.89h~(-1),分布相半衰期T_(1/2)α1.35h,排除相半衰期T_(1/2)β4.31h,逆向转运速率常数K_(21),大于正向转运速率常数K_(12),即K_(12)/K_(21)<1(0.37),中央室表观分布容积V。146.601/kg,廓清率C133.161/h,达峰时间T_(max)1.56h,血中毒物峰值浓度C_(max)2473.28ng/ml。~(14)G-二氯苯醚菊酯主要蓄积在脂肪内,其次为肝、肾。从尿、粪中排出,以尿为多。尿的排泄速率常数kell.38d~(-1),粪为0.90d~(-1);尿的排出半衰期为0.5天,粪为0.77天。实验表明,气管注入组比灌胃组吸收快、排泄慢。
Synthetic pyrethroid permethrin is an excellent insecticide. We injected ~ (14) Permethrin into the lungs of rats through the trachea, and the other by intragastric administration as a control for toxicokinetic studies. Blood concentration of a curve of time, in line with a two-rate open rate model. The first-order absorption rate constant Ka0.89h ~ (-1), the distribution half-life T 1/2 (1/2) α1.35h, the elimination half-life T 1/2 (1/3) β4.31h, the reverse transport rate constant K_ (21) greater than the positive transport rate constant K_ (12), ie K_ (12) / K_ (21) <1 (0.37) and the central chamber apparent volume of distribution. 146.601 / kg, clearance rate C133.161 / h, peak time T_ (max) 1.56h and blood poison peak concentration C_ (max) 2473.28ng / ml. ~ (14) G-permethrin accumulated mainly in fat, followed by liver and kidney. From the urine, excretion, urine and more. Urinary excretion rate constant kell.38d ~ (-1), manure was 0.90d ~ (-1); urinary excretion half-life of 0.5 days, manure was 0.77 days. Experiments show that tracheal injection group than intragastric absorption faster excretion.