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全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)是一种因感染或非感染病因作用于机体而引起的全身性炎症反应临床综合征。1985年由Coris首先提出,1991年美国胸病医师学会和美国危重病医学会(简称ACCP/SCCM)在芝加哥联合召开的讨论会上提出了SIRS的诊断标准。1996年荷兰鹿特丹召开的世界第二届儿科ICU大会上提出了儿科的诊断标准。自从SIRS提出后,一般认为以往的所谓的败血症,实际上等于全身性感染加上SIRS,即sepsis=infection+SIRS,而且进一步研究发现MOF或MODS的发生发展与SIRS密切相关,SIRS可向MODS转化,MODS是SIRS的后果,MOF是SIRS是严重的结局。
Systemic inflammatory response syndrome (SIRS) is a clinical syndrome of the systemic inflammatory response caused by an infectious or non-infectious etiology of the body. First proposed by Coris in 1985 in 1985, the American Thoracic Society and the American Society of Critical Care Medicine (ACCP / SCCM) presented a diagnostic criteria for SIRS at a joint symposium in Chicago. Pediatric diagnostic criteria were proposed at the Second World Congress of Pediatric ICU held in Rotterdam, the Netherlands in 1996. Since SIRS was proposed, the so-called sepsis in the past was generally considered to be equivalent to systemic infection plus SIRS, ie sepsis = infection + SIRS. Further studies showed that the development of MOF or MODS is closely related to SIRS, and SIRS can be transformed into MODS , MODS is the consequence of SIRS and MOF is SIRS a serious outcome.