已知Bestatin可以减少体内脑啡肽的水解。本工作研究Bestatin对小鼠记忆的影响。结果是:在两种行为实验中,训练后注射Bestatin.1.0mg/kg～2.0mg/kg能减弱记忆保持,与作者以前报告脑啡肽的作用类似。纳洛酮一方面能缓和Bstatin引起的记忆缺损,另一方面它本身对记忆的增强作用又可被Bestatin所抵消。这些结果提示内源性脑啡肽可能参与记忆巩固的调制。 Bestatin is known to reduce enkephalin hydrolysis in the body. This work to study the effects of Bestatin on memory in mice. The result: In both behavioral experiments, Bestatin 1.0 to 2.0 mg / kg after injection decreased memory retention similar to what the authors previously reported enkephalin. Naloxone can alleviate the memory deficits caused by Bstatin on the one hand, and on the other hand, its own memory-enhancing effect can be offset by Bestatin. These results suggest that endogenous enkephalin may be involved in memory consolidation modulation.