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目的:探讨地诺前列酮(普贝生)用于足月胎膜早破患者计划分娩的有效性及安全性。方法:选取计划分娩的单胎初产妇140例,均有计划分娩指征,分为实验组(胎膜早破组)59例、对照组(胎膜未破组)81例。观察用药前后宫颈Bishop评分,用药至临产及分娩的时间、用药24 h阴道分娩率,改用缩宫素使用率,手术产率,新生儿Apgar评分及有无不良反应,产后24 h出血量、产褥感染情况。结果:两组的宫颈Bishop评分、用药后至出现规律宫缩,总产程,产后出血,产褥病率及Apgar评分,新生儿窒息率差异均无统计学意义。结论:普贝生用于足月胎膜早破者计划分娩是有效和安全的,对临床有着重要的指导意义。
Objective: To investigate the efficacy and safety of dinoprostone (Probep) for planned delivery in term preterm premature rupture of membranes. Methods: A total of 140 singleton primiparous women scheduled for delivery were enrolled in this study. All of them were planned for delivery. They were divided into experimental group (premature rupture of membranes group) 59 cases and control group (unbroken membranes group) 81 cases. Bishop cervical score before and after treatment, medication to labor and delivery time, medication 24 h vaginal delivery rate, use of oxytocin use rate, surgical yield, neonatal Apgar score and whether the adverse reactions, 24 h postpartum hemorrhage, Puerperal infection. Results: There was no significant difference in cervical Bishop score, regular contractions, total labor, postpartum hemorrhage, puerperal morbidity and apgar score, neonatal asphyxia after treatment. Conclusion: Pubei students for full-term premature rupture of membranes scheduled delivery is effective and safe, has an important clinical significance.