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目的:观察探讨钕激光与欧柏宁治疗正畸病人口腔溃疡的临床对比效果.方法:选取我院2020年6月-2021年5月期间所收治的正畸患者有溃疡的50例,随机将该50例患者分为研究组和对照组,各25例,其中对照组使用欧柏宁[1]治疗,研究组给予口腔双波长激光治疗系统(型号:M021-5AF/1)钕激光治疗[2],观察对比两组患者的治疗效果,并做统计分析.结果:研究组总有效率为88.00％;对照组总有效率为72.00％,两组患者的治疗效果比较有明显差异(P＜0.05),具有统计学意义;两组治疗期间不良反应发生率无明显“,”Objective: To observe and explore the clinical comparative effect of neodymium laser and obernine in the treatment of oral ulcer in orthodontic patients. Methods: 50 orthodontic patients with ulcers treated in our hospital from June 2020 to May 2021 were randomly divided into study group and control group, with 25 cases in each group. The control group was treated with obernine [1] , and the study group was treated with neodymium laser with oral dual wavelength laser treatment system (model: m021-5af / 1) [2]. The therapeutic effects of the two groups were observed and compared, And do statistical analysis. Results: the total effective rate of the study group was 88.00％; The total effective rate of the control group was 72.00％. There was significant difference between the two groups (P＜ 0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P＞ 0.05); The improvement of pain in the study group was significantly higher than that in the control group (P＜ 0.05). The disappearance time of edema, congestion and pain and the average duration of ulcer in the study group were significantly shorter than those in the control group (P＜0.05). Conclusion: neodymium laser treatment with oral dual wavelength laser treatment system (model: m021-5af / 1) is effective in the treatment of orthodontic patients with oral ulcer, which is significantly better than that with obernine. It can more effectively alleviate the pain of patients without adverse reactions, and significantly shorten the time of edema, congestion, pain disappearance and the average time of ulcer [3], It has good curative effect on orthodontic patients with oral ulcer and is worthy of clinical promotion.