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全身炎性反应综合征(systemic inflammation response syndrome,SIRS)是多种疾病发展至多器官功能障碍综合征(multiple organs dysfunction syndrome,MODS)的前期表现。中性粒细胞,又名多形核白细胞(polymor-phonuclear neutrophil,PMN)是重要的炎症效应细胞,其凋亡延迟或障碍进而导致炎症反应持续发展和加剧是SIRS的主要病理生理过程。线粒体细胞色素c(cytochrome c,Cyt-c)是重要的凋亡蛋白,通过内源性和外源性等多种凋亡途径参与PMN凋亡。深入探讨SIRS时PMN凋亡异常的分子机制,研究线粒体Cyt-c在PMN凋亡中的作用,寻找诱导PMN适时、适度凋亡的有效方法,对于限制组织损伤、控制炎症反应、减轻SIRS有重要意义。
Systemic inflammatory response syndrome (SIRS) is a pre-manifestation of multiple organ dysfunction syndrome (MODS). Neutrophils, also known as polymor-phonuclear neutrophils (PMNs), are important inflammatory effector cells. The delayed or obstructive apoptosis of neutrophils leads to the persistent development and exacerbation of inflammation, which is the major pathophysiological process of SIRS. Cytochrome c (Cyt-c) is an important apoptotic protein that participates in the apoptosis of PMN through various apoptosis pathways, such as endogenous and exogenous. In order to investigate the molecular mechanism of apoptosis of PMN in SIRS and to investigate the role of mitochondrial Cyt-c in the apoptosis of PMN, it is necessary to find an effective way to induce PMN timely and moderately apoptosis, which is important for limiting tissue injury, controlling inflammatory response and alleviating SIRS significance.