本文报道了在以间苯三酚为原料合成血竭素的过程中,改进了中间体2,4,6-三羟基苯甲酸及2,6-二羟基-4-甲氧基-3-甲酰基-5-甲基苯甲酸甲酯的操作方法。以间苯三酚制备2,4,6-三羟基苯甲酸,收率为92%,较文献值提高约37%。以2,6-二羟基-4-甲氧基-3-甲基苯甲酸甲酯制备2,6-二羟基-4-甲氧基-3-甲酰基-5-甲基苯甲酸甲酯时,改变了氰化锌的用量,并去掉毒性极大的氢氰酸,收率为66.7%(文献收率64.6%)。 This paper reports the use of phloroglucin as raw materials in the synthesis of dracorhodin, improved 2,4,6-trihydroxybenzoic acid and 2,6-dihydroxy-4-methoxy-3-methyl Method of Procedure for Methyl Acyl-5-Methylbenzoate. The yield of 2,4,6-trihydroxybenzoic acid from phloroglucinol was 92%, which was 37% higher than the literature value. When 2,6-dihydroxy-4-methoxy-3-formyl-5-methylbenzoic acid methyl ester was prepared from methyl 2,6-dihydroxy-4-methoxy-3-methylbenzoate , Changed the amount of zinc cyanide, and removed the most toxic hydrocyanic acid, the yield was 66.7% (literature yield 64.6%).