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目的 探讨妊娠高血压综合征 (妊高征 )患者血浆止凝血分子标志物水平变化的意义。方法 对 4 5例妊高征孕妇 (妊高征组 ,其中轻度 2 0例、中度 15例、重度 10例 )及 2 0例正常孕妇 (正常妊娠组 )分娩前后的血浆止凝血分子标志物进行检测。其中 ,采用酶联免疫吸附试验 (ELISA)检测两组孕妇分娩前后的P 选择素、凝血酶原片段 1+2 (F1+2 )、D 二聚体、纤溶酶抗纤溶酶复合物(PAP) ;采用发色底物法检测两组孕妇分娩前后的抗凝血酶活性。结果 (1)P 选择素 :妊高征组中、重度孕妇分娩前分别为 (6 6± 2 4 ) μg/L、(80± 30 ) μg/L ,正常妊娠组为 (49± 15 ) μg/L ,两组比较 ,差异有显著性 (P <0 0 5 )。分娩后妊高征组重度孕妇为 (6 5± 34) μg/L ,正常妊娠组为 (40± 12 ) μg/L ,两组比较 ,差异有显著性 (P <0 0 5 )。 (2 )F1+2 :妊高征组轻、中、重度孕妇分娩前分别为 (2 2± 0 2 )nmol/L、(2 3± 0 4 )nmol/L、(2 2± 0 2 )nmol/L ,均明显高于正常妊娠组的 (1 2± 0 3)nmol/L ,两组比较 ,差异有显著性 (P <0 0 5 )。 (3)D 二聚体 :妊高征组轻、中、重度孕妇分别为 (0 7± 0 1)mg/L、(0 7± 0 3)mg/L、(0 8± 0 2 )mg/L ,正常妊娠组为 (0 4± 0 1)mg/L ,妊高征组显著高于正常妊娠?
Objective To investigate the significance of plasma coagulation markers in patients with pregnancy induced hypertension (PIH). Methods 45 cases of pregnancy induced hypertension (PIH group, mild 20 cases, moderate 15 cases, severe 10 cases) and 20 normal pregnant women (normal pregnancy group) before and after delivery of plasma coagulation markers Material testing. Among them, P-selectin, prothrombin fragment 1 + 2 (F1 + 2), D dimer, plasmin anti-plasmin complex ( PAP). The chromogenic substrate method was used to detect the antithrombin activity before and after delivery in two groups of pregnant women. Results (1) In P-selectin group, severe pregnant women were (6 6 ± 2 4) μg / L and (80 ± 30) μg / L before delivery and 49 ± 15 μg / L, the difference between the two groups was significant (P <0 05). The number of severe pregnant women after delivery was (6 5 ± 34) μg / L in pregnant women with severe pregnancy, and (40 ± 12) μg / L in normal pregnancy. There was significant difference between the two groups (P 0.05). (2) F1 + 2: (2 2 ± 0 2) nmol / L, (2 3 ± 0 4) nmol / L before treatment and (2 2 ± 0 2) nmol / L, both of which were significantly higher than that of normal pregnancy group (1 2 ± 0 3) nmol / L. There was significant difference between the two groups (P <0.05). (3) D dimer: (0 7 ± 0 1) mg / L, (0 7 ± 0 3) mg / L, (0 8 ± 0 2) mg / L, normal pregnancy group (0 4 ± 0 1) mg / L, pregnancy induced hypertension group was significantly higher than normal pregnancy?