目的总结东北地区结外非霍奇金淋巴瘤的临床特点。方法对81例结外非霍奇金淋巴瘤所占比例、发生部位、发病年龄、首发症状及确诊前病程进行分析。结果本病占非霍奇金淋巴瘤的31.2%;原发部位前五位为胃肠道、鼻、头颈、口咽和脾;发病高峰年龄50~59岁;首发症状多样;确诊前病程1周~10 a。结论东北地区原发结外非霍奇金淋巴瘤发病率高,高峰年龄大,首发症状无特异性,误诊率高。 Objective To summarize the clinical features of non-Hodgkin’s lymphoma in Northeast China. Methods 81 cases of extranodal non-Hodgkin’s lymphoma, the proportion of the site of occurrence, age of onset, first symptom and the pre-diagnosis course of disease were analyzed. Results The disease accounted for 31.2% of non-Hodgkin’s lymphoma; the top five primary sites were gastrointestinal tract, nose, head and neck, oropharynx and spleen; the peak age of onset was 50-59 years; the first symptoms were diverse; Week ~ 10 a. Conclusions The incidence of primary non-Hodgkin’s lymphoma in Northeast China is high, the age at peak is high, the first symptom is nonspecific and the rate of misdiagnosis is high.