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Wessely(1915)观察到亚硝酸异戊酯引起猫眼压升高以来,有机硝酸盐应用于青光眼一直被认为是禁忌的。尽管一些关于亚硝酸异戊酯对眼压作用的研究结果是有争议的,而且没有一例因使用硝酸甘油而引起青光眼的报告,但是有些作者仍指出有机硝酸盐对青光眼病人要慎用。由于青光眼和冠心病均常见于老年人,故本文旨在探讨有机硝酸盐对眼压的作用。研究对象为10例房角开放,无青光眼病史正常眼压的志愿者,25名开角型青光眼患者和20名窄角型青光眼患者共3组。静脉滴注硝酸甘油可使眼压下降,眼压与剂量的关系如下:9.7μg/分眼压下降约9%;19.4
Wessely (1915) observed that the use of organic nitrates in glaucoma has been regarded as contraindicated since isoamyl nitrite caused a rise in intraocular pressure in cats. Although some studies on intraocular pressure of isoamyl nitrite are controversial and there is no report of glaucoma caused by the use of nitroglycerin, some authors still point out that organic nitrates should be used with caution in patients with glaucoma. Because glaucoma and coronary heart disease are common in the elderly, so this article aims to explore the role of organic nitrate on intraocular pressure. The subjects were 10 volunteers with open angle, normal intraocular pressure without history of glaucoma, 25 patients with open-angle glaucoma and 20 patients with narrow-angle glaucoma. Intraocular pressure decreased by intravenous nitroglycerin, intraocular pressure and dose relationship as follows: 9.7μg / min intraocular pressure decreased by about 9%; 19.4