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目的观察二甲双胍治疗糖耐量减低(IGT)的临床疗效。方法86例患者口服二甲双胍1000mg/d,疗程3mo后观察治疗前后体重、血压、心率、简化葡萄糖耐量试验、血脂的变化。结果86例患者治疗后血糖水平明显下降,差异有显著性意义(P<0.05);体重稍下降,差异无显著性意义(P>0.05);血压、心率、血脂等无明显变化。结论二甲双胍治疗IGT疗效可靠。
Objective To observe the clinical efficacy of metformin in the treatment of impaired glucose tolerance (IGT). Methods 86 patients received oral metformin 1000mg / d. After 3 months of treatment, body weight, blood pressure, heart rate, simplified glucose tolerance test, and blood lipid changes were observed before and after treatment. Results The blood glucose level of 86 patients decreased significantly after treatment, with significant difference (P <0.05). The body weight decreased slightly with no significant difference (P> 0.05). There was no significant change in blood pressure, heart rate and blood lipids. Conclusion Metformin treatment of IGT is reliable.