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目的 研究脑梗死微栓子与粘附分子的相关性。方法 选择76例研究对象,通过TCD自动监测微栓子信号(MES)后分为研究组(MES≥7个/30 min)、对照组(MES介于1~6个/30 min)及空白组(未检出MES),均用双抗体夹心ELISA法测定血清sICAM 1、sVCAM 1、sE selectine 水平。结果 研究组sI CAM 1、sVCAM 1、sE selectine水平明显高于对照组、空白组(P<0.01),且对照组sICAM 1、sVCAM 1、sE selectine水平高于空白组(P<0.05)。结论 粘附分子参与了微栓子的形成过程,两者是发生脑梗死的危险因素,及时给予药物干预对防治脑梗死有积极意义。
Objective To study the correlation between cerebral infarction microemboli and adhesion molecules. Methods Totally 76 study subjects were selected and were divided into study group (MES≥7 / 30 min), control group (MES 1 ~ 6/30 min) and blank group (MES not detected), serum sICAM 1, sVCAM 1, sE selectine levels were measured by double antibody sandwich ELISA. Results The levels of sICAM1, sVCAM1 and sE selectine in the study group were significantly higher than those in the control group and the blank group (P <0.01), and the levels of sICAM1, sVCAM1 and sE selectine in the control group were higher than those in the blank group (P <0.05). Conclusions Adhesion molecules are involved in the formation of microemboli, both of which are risk factors of cerebral infarction. Timely drug intervention is of great significance in prevention and treatment of cerebral infarction.