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[目的]探讨术前外周血中淋巴细胞与单核细胞比值(LMR)在乳腺癌患者预后评估中的价值。[方法]回顾性分析2006年1月至2010年12月在新疆军区总医院经术后病理证实92例乳腺癌患者的临床资料。通过建立受试者工作特征曲线,确定术前LMR最佳临界值为5.83;按术前LMR值分为高LMR组(LMR≥5.83)与低LMR组(<5.83)。[结果]92例患者术前LMR范围1.47~12.33,平均值为6.00,中位值为5.89。高LMR组与低LMR组患者的临床病理特征差异均无统计学意义(均P>0.05)。高LMR组和低LMR组患者的5年生存率分别为89.4%和76.7%(P<0.001)。Cox多因素分析结果显示LMR是影响患者预后的独立因素(RR=3.948,95%CI:1.770~8.808)。[结论]术前外周血中LMR是预测乳腺癌患者预后的独立因素。
[Objective] To investigate the value of preoperative lymphocyte to monocyte ratio (LMR) in the prognosis evaluation of breast cancer patients. [Methods] The clinical data of 92 cases of breast cancer confirmed by postoperative pathology in Xinjiang Military General Hospital from January 2006 to December 2010 were retrospectively analyzed. By setting the working curve of the subjects, the best critical value of preoperative LMR was 5.83. According to the preoperative LMR, it was divided into high LMR group (LMR≥5.83) and low LMR group (<5.83). [Results] The preoperative LMR ranged from 1.47 to 12.33 in 92 patients, with an average of 6.00 and a median of 5.89. There were no significant differences in the clinicopathological characteristics between high LMR group and low LMR group (all P> 0.05). The 5-year survival rates of high LMR group and low LMR group were 89.4% and 76.7%, respectively (P <0.001). Cox multivariate analysis showed that LMR was an independent factor affecting the prognosis of patients (RR = 3.948, 95% CI: 1.770-8.808). [Conclusion] The preoperative LMR in peripheral blood is an independent factor to predict the prognosis of patients with breast cancer.