文章简介埃博拉病毒(尤其是扎伊尔型)是引起人或灵长类动物发生埃博拉出血热的烈性病毒,由于其高致命性,并缺乏批准的药物及疫苗,而引起广泛关注。目前针对该病毒的药物开发,多为对已知药物的广谱性筛选。本研究首次发现其基因组中存在保守度较高的特殊结构核酸——RNA G-四链体,并以之作为一个新的 Introduction Ebola virus, especially Zaire, is a potent virus that causes Ebola haemorrhagic fever in humans or primates and has drawn widespread public concern due to its high mortality and lack of approved drugs and vaccines . The current drug development for the virus, mostly for the broad spectrum of known drugs screening. In the present study, we found for the first time that a highly conserved structure-specific nucleic acid, RNA G-quadruplex, is present in the genome and used as a new