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目的 观察二甲双胍和食物纤维预防糖耐量低减 (IGT)人群进展为 2型糖尿病 (DM)的作用。 方法 以口服 75 g葡萄糖耐量试验 (OGTT)确诊 (WHO标准 )的 IGT2 93例中男 2 16例 ,女 77例。入选者年龄 35岁以上 ,体重指数 (BMI)在 19kg/ m2以上。随机分为对照组 72例 ,教育组 5 7例 ,食物纤维组 84例 ,二甲双胍组 80例。对照组进行一般的健康教育 ;教育组进行饮食指导 ,每半年1次 ;食物纤维组除健康教育外 ,每日口服食物纤维 12 g;二甲双胍组每日口服二甲双胍 0 .75 g,分 3次餐后口服。对四组参试者每半年作 1次 OGTT,同时测身高、体重、BMI、12 h尿白蛋白 ,复查日当天不服干预药物或食物纤维。共观察 3年。若 2次 OGTT或最后 1次复查结果为 DM,则判断为已发展为 DM。 结果 2 93例 IGT在观察中有 2 3例 (7.8% )退出。空腹血糖 (FBS)和服糖后 1h血糖 (1hPBS)在对照组、教育组和食物纤维组均较治疗前略有升高 ,但在二甲双胍治疗组均有下降。四组间FBS比较 F=8.118,P<0 .0 1,四组间 1h PBS比较 F=3.6 97,P=0 .0 12。观察期末对照组 16例 (2 5 .0 % )、教育组 11例 (2 1.6 % )、食物纤维组 13例 (16 .3% )、二甲双胍组 7例 (9.3% )转化为 DM,二甲双胍组在治疗后 DM转化率明显低于对照组 (χ2 =6 .318,P<0 .0
Objective To observe the effect of metformin and dietary fiber on prevention of type 2 diabetes mellitus (DM) in people with impaired glucose tolerance (IGT). Methods Two hundred and seventy-six men and 77 women with IGT2 were diagnosed by OGTT (WHO standard). Participants age 35 years of age or older, body mass index (BMI) 19kg / m2 or more. Randomly divided into control group of 72 cases, 57 cases of education group, 84 cases of dietary fiber group, 80 cases of metformin group. Control group for general health education; education group diet guidance, once every six months; dietary fiber group in addition to health education, oral daily dietary fiber 12 g; metformin group daily oral metformin 0 .75 g, divided into 3 meals After oral administration. OGTT was performed once every six months for the four groups of participants. Height, weight, BMI, and urine albumin for 12 hours were also measured. On the day of review, they refused to accept the intervention drug or dietary fiber. A total of 3 years of observation. If the result of the second OGTT or the last review is DM, it is determined that DM has been developed. Results In 2 93 cases of IGT, 23 patients (7.8%) were withdrawn. Fasting blood glucose (FBS) and 1h blood sugar (1hPBS) in the control group, education group and dietary fiber group were slightly higher than those before treatment, but decreased in metformin-treated group. FBS between the four groups compared F = 8.118, P <0.01, 1h PBS between the four groups compared F = 3.697, P = 0.012. At the end of the observation period, 16 cases (25.0%) in control group, 11 cases (21.6%) in education group, 13 cases (16.3%) in dietary fiber group and 7 cases (9.3%) in metformin group were converted to DM, metformin group DM conversion rate after treatment was significantly lower than the control group (χ2 = 6 .318, P <0 .0