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目的探讨纤溶酶原激活物抑制剂-1(PAI-1)在急性心肌梗死(AMI)发病中的作用。方法应用发色底物法测定中国汉族AMI患者56例(男44,女12,平均年龄67±10岁)和正常对照组55例(男42,女13,年龄68±8岁)血浆PAI-1活性,并分析环境因素对PAI-1水平的影响。结果 (1)AMI组和正常对照组的血浆PAI-1水平分别为O.90±O.13Au/ml和O.72±O.13Au/ml,两组间比较有显著性差异(P<0.001)。(2)吸烟、高血压病史、既往血栓性疾病病史、冠心病家族史、体重指数(BMI)、三酰甘油(TG)、血糖水平均与血浆PAI-1水平呈正相关,多元逐步回归分析显示,高血压病史、冠心病家族史是血浆PAI-1水平的独立预测因素。结论血浆PAI-1水平增加是心肌梗死(MI)的危险因素;(2)高血压、冠心病家族史为PAI-1水平的独立决定因素。
Objective To investigate the role of plasminogen activator inhibitor-1 (PAI-1) in the pathogenesis of acute myocardial infarction (AMI). Methods The colorimetric method was used to determine the plasma level of PAI-1 in 56 Chinese Han (AMI) patients (male 44, female 12, average age 67 ± 10 years) and 55 normal controls (male 42, female 13, age 68 ± 8 years) 1 activity, and analyze the impact of environmental factors on the level of PAI-1. Results (1) Plasma levels of PAI-1 in AMI group and normal control group were respectively O.90 ± 0.13Au / ml and 0.72 ± 0.13Au / ml, with significant difference between the two groups (P <0.001 ). (2) The history of smoking, the history of hypertension, the history of previous thrombotic diseases, the family history of coronary heart disease, body mass index (BMI), triglyceride (TG) and blood glucose level were positively correlated with plasma PAI-1 levels. Multiple stepwise regression analysis , History of hypertension, family history of coronary heart disease are independent predictors of plasma PAI-1 level. Conclusions Plasma PAI-1 level is a risk factor for myocardial infarction (MI). (2) Family history of hypertension and coronary heart disease is the independent determinant of PAI-1 level.